Grimond (GS7), 12-2 pm, 27 March 2017.
This lunchtime discussion will include short presentations from a number of visitors, staff and research students at the University of Kent outlining their current research in the broad area of abortion law and policy. There will be ample time for discussion and a sandwich lunch will be provided.
Presenters will include Kate Gleeson (Macquarie Law School and visitor, KCLGS); Joanna Mishtal (University of Central Florida and visitor, KCLGS); Christy Zink (Washington University and visitor, KCLGS); Ann Furedi (CEO, bpas); Ellie Lee (SSPSSR); Clare Parker (KLS); Verity Pooke (SSPSSR); and Sally Sheldon (KLS).
‘Tamara Ecclestone breastfeeding pictures: Why were they controversial?’ with comment by Ellie Lee
Don’t you just love it when an acronym comes together? In the pages of last week’s edition of Nature (see BioNews 887), a consortium that styles itself with the moniker ‘GIANT’ (short for Genetic Investigation of Anthropometric Traits – I’ll try to keep further puns to a minimum) describes 83 novel but rare genetic variants that are related to human height. The study involved more than 700,000 people and the dark art of genome-wide association studies, or GWAS. Basically, GWAS use DNA arrays or ‘chips’ – collections of known DNA variations – to search the genomes of a large number of individuals for these variations, and so link them to traits. The more people are analysed, the more ‘power’ the study is said to have, in that it can accurately link less common variations to traits. Height is a complex trait involving many genes, and this study brings the total known to be involved to around 700.
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Dr Peter Ellis from the School of Biosciences recently published a paper in the journal Human Molecular Genetics on the quality control mechanisms during sperm production.
During the production of eggs and sperm (gametes) in mammals, there is a need for strict quality control. This includes ensuring correct cell division, that exactly half the genome makes it into the final product, that the right amount of genetic recombination (the process through which we are all different) occurs, and that the DNA packaged into the egg and sperm cells is undamaged. One of the ‘checkpoint’ pathways the developing gametes use to do this is ‘meiotic silencing’, in which the cell tests whether each chromosome has correctly paired up with its partner, and inactivates the genes on any chromosome that is not paired. Dr Ellis’ work shows that a gene on the Y chromosome, Zfy2 controls the stringency of meiotic silencing. In male mice lacking Zfy2, meiotic silencing is ‘leaky’, the resulting germ cells show a range of developmental problems, and the mice are sterile.
Further details can be found here.
Both staff and postgraduate students from CISoR have again received accolades for their research winning two of this year’s 2017 University Research Prizes. These prizes were launched as part of the University’s 50th anniversary year and recognise outstanding research across the University. Dr Rebecca O’Connor, a former PhD student from the Griffin lab receives the overall University Prize for Postgraduate Research and Professor Darren Griffin the Faculty of Sciences Prize for Advanced Research.
Congratulations to our winners who will pick up their prizes at an Awards Ceremony in April.
Darren Griffin was quoted several times in January and February news items including the following:
Major report prepares ground for genetic modification of human embryos:
Women who work nightshift may be damaging fertility, as study shows they have fewer eggs:
Pig and human combination embryos grown for first time:
Researchers at the Royal Veterinary College (RVC) and the University of Kent have developed a new cost effective approach to mapping and assembling genomes, using a novel method that is particularly effective for bird species. Developed with funding from the Biotechnology and Biological Sciences Research Council (BBSRC), this new method enables geneticists to assemble complete (chromosome-level) genome assemblies.
Publication details can be found here