{"id":833,"date":"2015-03-19T10:28:17","date_gmt":"2015-03-19T10:28:17","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=833"},"modified":"2015-03-19T10:28:17","modified_gmt":"2015-03-19T10:28:17","slug":"research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/","title":{"rendered":"Research Seminar:  Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins"},"content":{"rendered":"<p><strong>Professor Jane Clarke, Department of Chemistry, University of Cambridge<\/strong><\/p>\n<p><strong>Wednesday 25th March, 4.00 p.m., Stacey Lecture Theatre 1<\/strong><\/p>\n<p>Most proteins in Nature are not the simple, single domain structures that appear most often in the databases, but larger multidomain proteins and even larger assemblies. \u00a0Examples include the giant muscle protein titiin, spectrin, a protein of the cytoskelton, and \u201chub\u201d proteins and transcription factors, such as CBP and P53, which use disordered regions that fold upon binding to form large multi-protein complexes. \u00a0We use a multidisciplinary approach to study the folding, misfolding and assembly of these larger proteins and their complexes. \u00a0In my talk I will describe some of our recent discoveries.<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/&amp;t=Research Seminar:  Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar:  Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins%20https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/&amp;title=Research Seminar:  Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/&amp;title=Research Seminar:  Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Jane Clarke, Department of Chemistry, University of Cambridge Wednesday 25th March, 4.00 p.m., Stacey Lecture Theatre 1 Most proteins in Nature are not the &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/03\/19\/research-seminar-biophysics-investigating-the-folding-misfolding-and-assembly-of-multidomain-proteins\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/833"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=833"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/833\/revisions"}],"predecessor-version":[{"id":877,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/833\/revisions\/877"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}