{"id":829,"date":"2015-02-26T09:14:57","date_gmt":"2015-02-26T09:14:57","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=829"},"modified":"2015-02-26T09:14:57","modified_gmt":"2015-02-26T09:14:57","slug":"research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/","title":{"rendered":"Research Seminar:  Perception of host imposed oxidative stress by the human fungal pathogen Candida albicans"},"content":{"rendered":"<p><strong>Professor Janet Quinn, Institute for Cell and Molecular Biosciences, Newcastle University<\/strong><\/p>\n<p><strong>Wednesday 4th March, 4.00 p.m., Stacey Lecture Theatre 1<\/strong><\/p>\n<p><i>Candida <\/i><i>albicans<\/i> is an important fungal pathogen of humans causing approximately 400,000 life-threatening systemic infections each year. Stress responses are essential for this fungal pathogen to evade host anti-microbial defence mechanisms and to survive rapidly changing microenvironments found within diverse host niches. We are particularly interested in the sensing and signalling mechanisms employed by <i>C. <\/i><i>albicans<\/i> to perceive and respond to reactive oxygen species (ROS) encountered during infection. Upon contact with <i>C. <\/i><i>albicans<\/i>, the NADPH oxidase complex in phagocytic cells produces high levels of superoxide which is rapidly converted to H2O2. To survive in the phagocyte <i>C. <\/i><i>albicans<\/i> must mount a rapid transcriptional response to induce the expression genes encoding antioxidant and repair proteins. Furthermore, phagocytosis of <i>C<\/i>. <i>albicans<\/i> by macrophages, or exposure to ROS <i>in vitro<\/i>, initiates filamentous growth. In this talk I\u2019ll highlight how oxidation of specific signalling proteins plays a key role in the perception and regulation of both transcriptional and morphogenetic responses to ROS in <i>C. <\/i><i>albicans<\/i><i>.<\/i> In addition, I\u2019ll also describe some recent findings detailing mechanisms employed by the host to prevent the rapid oxidative stress responses needed for fungal survival.<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/&amp;t=Research Seminar:  Perception of host imposed oxidative stress by the human fungal pathogen Candida albicans' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar:  Perception of host imposed oxidative stress by the human fungal pathogen Candida albicans%20https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/&amp;title=Research Seminar:  Perception of host imposed oxidative stress by the human fungal pathogen Candida albicans' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/&amp;title=Research Seminar:  Perception of host imposed oxidative stress by the human fungal pathogen Candida albicans' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Janet Quinn, Institute for Cell and Molecular Biosciences, Newcastle University Wednesday 4th March, 4.00 p.m., Stacey Lecture Theatre 1 Candida albicans is an important &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/02\/26\/research-seminar-perception-of-host-imposed-oxidative-stress-by-the-human-fungal-pathogen-candida-albicans\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/829"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=829"}],"version-history":[{"count":1,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/829\/revisions"}],"predecessor-version":[{"id":830,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/829\/revisions\/830"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}