{"id":820,"date":"2015-01-30T09:15:47","date_gmt":"2015-01-30T09:15:47","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=820"},"modified":"2015-01-30T09:25:55","modified_gmt":"2015-01-30T09:25:55","slug":"research-seminar-the-machinery-of-bacterial-rna-turnover-processing-and-riboregulation","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2015\/01\/30\/research-seminar-the-machinery-of-bacterial-rna-turnover-processing-and-riboregulation\/","title":{"rendered":"Research Seminar: The machinery of RNA degradation, processing and riboregulation in E. coli."},"content":{"rendered":"

Professor Ben Luisi, Department of Biochemistry, University of Cambridge<\/strong><\/p>\n

Wednesday 4th February, 4.00 p.m., Stacey Lecture Theatre 1<\/strong>
\nSmall regulatory RNAs enrich the network complexity of post-transcriptional gene control in prokaryotes. In bacteria such as Escherichia coli <\/i>and Salmonella sp., the action of many small RNAs in silencing transcripts involves the endoribonuclease RNase E. The enzyme serves as the scaffold of a multi-protein assembly, known as the RNA degradosome, which plays a central role in many cellular RNA turnover and processing events.\u00a0 We describe the organisation and cellular localisation of the degradosome. and we present a model for how some sRNAs act in conjunction with the RNA chaperone Hfq to guide the ribonuclease to cleave targeted transcripts.<\/p>\n