{"id":756,"date":"2014-11-20T09:56:51","date_gmt":"2014-11-20T09:56:51","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=756"},"modified":"2014-11-20T09:56:51","modified_gmt":"2014-11-20T09:56:51","slug":"research-seminar-de-novo-protein-design-faster-better-fitter","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/11\/20\/research-seminar-de-novo-protein-design-faster-better-fitter\/","title":{"rendered":"Research Seminar: De Novo Protein Design: Faster, Better, Fitter"},"content":{"rendered":"

Professor Dek Woolfson, Schools of Chemistry and Biochemistry, & BrisSynBio, University of Bristol <\/strong><\/p>\n

Wednesday 26th November, 4.00 p.m., Stacey Lecture Theatre 1<\/strong><\/p>\n

We have developed a toolkit of de novo<\/i> peptides (1). These can be used as building blocks for the rapid construction of new protein structures and supramolecular assemblies. This talk will demonstrate the utility of this approach to make nanoscale protein pores (2, 3), and peptide-based nanocages (4). Potential applications of these structures and materials span nanoscience, synthetic biology and biotechnology.<\/p>\n

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  1. A Basis Set of de Novo Coiled-Coil Peptide Oligomers for Rational Protein Design and Synthetic Biology. <\/em>JM Fletcher, AL Boyle, M Bruning, GJ Bartlett, TL Vincent, NR Zaccai, CT Armstrong, EHC Bromley, PJ Booth, RL Brady, AR Thomson, and DN Woolfson.\u00a0 ACS Synthetic Biology<\/em> 6<\/em><\/strong>, 240-250 (2012)<\/li>\n
  2. A de novo peptide hexamer with a mutable channel. <\/em>NR Zaccai, B Chi, AR Thomson, AL Boyle, GJ Bartlett, M Bruning, N Linden, RB Sessions, PJ Booth, RL Brady and DN Woolfson. Nature Chemical Biology<\/em> 7<\/em><\/strong>, 935-941 (2011)<\/li>\n
  3. Computational design of water-soluble alpha-helical barrels. <\/em>AR Thomson, CW Wood, AJ Burton, GJ Bartlett, RB Sessions, RL Brady and DN Woolfson. Science<\/strong><\/em> 346,<\/strong> 485-488 (2014)<\/li>\n
  4. Self-assembling cages from coiled-coil peptide modules. <\/em>JM Fletcher, RL Harniman, FRH Barnes, AL Boyle, A Collins, J Mantell, TH Sharp, Antognozzi, PJ Booth, N Linden, MJ Miles, RB Sessions, P Verkade, and DN Woolfson.\u00a0 Science<\/em> 340<\/em><\/strong>, 595-599 (2013)<\/li>\n<\/ol>\n