{"id":487,"date":"2014-01-28T09:54:28","date_gmt":"2014-01-28T09:54:28","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=487"},"modified":"2014-01-28T09:54:28","modified_gmt":"2014-01-28T09:54:28","slug":"research-seminar-experimental-and-computational-approaches-to-understanding-allostery","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/","title":{"rendered":"Research Seminar: Experimental and computational approaches to understanding allostery."},"content":{"rendered":"<p><strong>Professor Jannette Carey, Department of Chemistry, Princeton University, USA<\/strong><\/p>\n<p><strong>Monday 3rd February 2014, 4.00 p.m., Marlowe Lecture Theatre 1<\/strong><\/p>\n<p>The binding of one ligand to a protein can alter the affinity of another ligand; this is the basic definition of allostery.\u00a0\u00a0\u00a0Mechanisms of allosteric signal transmission have been elusive. Results will be presented from a synergistic approach that combines measurements of ligand binding affinity using complementary<br \/>\nexperimental methods and molecular dynamics simulations of ligand occupancy and conformational states.<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/&amp;t=Research Seminar: Experimental and computational approaches to understanding allostery.' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Experimental and computational approaches to understanding allostery.%20https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/&amp;title=Research Seminar: Experimental and computational approaches to understanding allostery.' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/&amp;title=Research Seminar: Experimental and computational approaches to understanding allostery.' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Jannette Carey, Department of Chemistry, Princeton University, USA Monday 3rd February 2014, 4.00 p.m., Marlowe Lecture Theatre 1 The binding of one ligand to &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2014\/01\/28\/research-seminar-experimental-and-computational-approaches-to-understanding-allostery\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/487"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=487"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/487\/revisions"}],"predecessor-version":[{"id":490,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/487\/revisions\/490"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}