{"id":1961,"date":"2018-10-10T10:35:55","date_gmt":"2018-10-10T09:35:55","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1961"},"modified":"2018-10-10T10:35:55","modified_gmt":"2018-10-10T09:35:55","slug":"research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/","title":{"rendered":"Research Seminar: Extracting information from imaging data by fitting mathematical models"},"content":{"rendered":"<p><b>Professor Nigel Burroughs, <\/b><b>Mathematics <\/b><b>Institute and Warwick Systems Biology <\/b><b>Centre, University of Warwick<\/b><\/p>\n<p><b>Tuesday <\/b><b>16th<\/b> <b>October, 1.00 p.m., Stacey Lecture Theatre 1<\/b><\/p>\n<p>With the increasing sophistication of microscope technology (e.g. super resolution, light sheet), interpreting the data and extracting reliable information increasingly requires mathematical and statistical methods. I will discuss work with Andrew McAinsh on imaging kinetochore dynamics and conformational changes. During metaphase, congressed chromosome oscillate across the metaphase plate. By fitting a mechanical model to those oscillations we inferred the forces acting on the kinetochore which lead to the tension-clock model of directional switching. This lead to an investigation of kinetochore compliance to forces and distinguishing conformational changes under loading and microtubule attachment.<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/&amp;t=Research Seminar: Extracting information from imaging data by fitting mathematical models' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Extracting information from imaging data by fitting mathematical models%20https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/&amp;title=Research Seminar: Extracting information from imaging data by fitting mathematical models' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/&amp;title=Research Seminar: Extracting information from imaging data by fitting mathematical models' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Nigel Burroughs, Mathematics Institute and Warwick Systems Biology Centre, University of Warwick Tuesday 16th October, 1.00 p.m., Stacey Lecture Theatre 1 With the increasing &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/10\/10\/research-seminar-extracting-information-from-imaging-data-by-fitting-mathematical-models\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1961"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=1961"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1961\/revisions"}],"predecessor-version":[{"id":1963,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1961\/revisions\/1963"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=1961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=1961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=1961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}