{"id":1846,"date":"2018-03-21T09:23:21","date_gmt":"2018-03-21T09:23:21","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1846"},"modified":"2018-03-21T09:23:21","modified_gmt":"2018-03-21T09:23:21","slug":"research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/","title":{"rendered":"Research Seminar: Alloimmunity, the proteome and antibody repertoire analytics: predicting inhibitor risk in haemophilia A patients."},"content":{"rendered":"<p><b>Dr.<\/b><b> Adrian Shepherd, <\/b><strong>Department of Biological Sciences, Birkbeck, University of London<\/strong><\/p>\n<p><b>Tuesday 27th March, 1.00 p.m., Stacey Lecture Theatre 1<\/b><\/p>\n<p>Around 20% of haemophilia A (HA) patients develop alloantibodies that inhibit the activity of replacement Factor VIII, the standard treatment for HA. Given the diverse genetic causes of HA \u2013 includes nearly 1,000 distinct missense mutations \u2013 together with the notorious complexity of the immune system, predicting which patients are at risk of developing inhibitors is a huge challenge. This talk will explain two contrasting approaches to inhibitor risk prediction: the first focuses on the boundary between self and non-self; the second involves using NGS antibody repertoire sequencing to detect the early signs of inhibitor development.<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/&amp;t=Research Seminar: Alloimmunity, the proteome and antibody repertoire analytics: predicting inhibitor risk in haemophilia A patients.' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Alloimmunity, the proteome and antibody repertoire analytics: predicting inhibitor risk in haemophilia A patients.%20https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/&amp;title=Research Seminar: Alloimmunity, the proteome and antibody repertoire analytics: predicting inhibitor risk in haemophilia A patients.' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/&amp;title=Research Seminar: Alloimmunity, the proteome and antibody repertoire analytics: predicting inhibitor risk in haemophilia A patients.' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Dr. Adrian Shepherd, Department of Biological Sciences, Birkbeck, University of London Tuesday 27th March, 1.00 p.m., Stacey Lecture Theatre 1 Around 20% of haemophilia A &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/21\/research-seminar-alloimmunity-the-proteome-and-antibody-repertoire-analytics-predicting-inhibitor-risk-in-haemophilia-a-patients\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1846"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=1846"}],"version-history":[{"count":1,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1846\/revisions"}],"predecessor-version":[{"id":1847,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1846\/revisions\/1847"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=1846"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=1846"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=1846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}