{"id":1841,"date":"2018-03-14T09:14:25","date_gmt":"2018-03-14T09:14:25","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1841"},"modified":"2018-03-14T09:14:25","modified_gmt":"2018-03-14T09:14:25","slug":"research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/","title":{"rendered":"Research Seminar: Structure and function of staphylococcal proteins involved in biofilm infections"},"content":{"rendered":"<p><b>Professor Jennifer Potts, <\/b><strong>Department of Biology, University of York<\/strong><\/p>\n<p><b>Tuesday 20th March, 1.00 p.m., Stacey Lecture Theatre 1<\/b><\/p>\n<p>&nbsp;<\/p>\n<p>Cell wall-attached proteins of Gram positive bacteria such as <i>Staphylococcus aureus<\/i> can play important roles in infection including the formation of biofilms on medical devices, an important clinical problem. Several of these proteins have a common organization that includes a globular N-terminal domain, a repetitive central region and a cell-wall attachment site near the C-terminus. We are using a variety of biophysical and structural techniques including NMR spectroscopy, X-ray crystallography and small angle X-ray scattering to study both the N-terminal domain and the repetitive region to understand the relationship between structure and function. The work has demonstrated, for example, that the <i>S. aureus<\/i> surface protein SasG can form a highly-elongated structure from a single protein chain.<a href=\"http:\/\/blogs.kent.ac.uk\/biosciences\/files\/2018\/03\/Potts-image.jpg\"><img loading=\"lazy\" class=\"size-medium wp-image-1842 aligncenter\" src=\"http:\/\/blogs.kent.ac.uk\/biosciences\/files\/2018\/03\/Potts-image-300x54.jpg\" alt=\"\" width=\"300\" height=\"54\" srcset=\"https:\/\/blogs.kent.ac.uk\/biosciences\/files\/2018\/03\/Potts-image-300x54.jpg 300w, https:\/\/blogs.kent.ac.uk\/biosciences\/files\/2018\/03\/Potts-image-768x139.jpg 768w, https:\/\/blogs.kent.ac.uk\/biosciences\/files\/2018\/03\/Potts-image.jpg 939w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/&amp;t=Research Seminar: Structure and function of staphylococcal proteins involved in biofilm infections' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Structure and function of staphylococcal proteins involved in biofilm infections%20https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/&amp;title=Research Seminar: Structure and function of staphylococcal proteins involved in biofilm infections' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/&amp;title=Research Seminar: Structure and function of staphylococcal proteins involved in biofilm infections' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Jennifer Potts, Department of Biology, University of York Tuesday 20th March, 1.00 p.m., Stacey Lecture Theatre 1 &nbsp; Cell wall-attached proteins of Gram positive &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/03\/14\/research-seminar-structure-and-function-of-staphylococcal-proteins-involved-in-biofilm-infections\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1841"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=1841"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1841\/revisions"}],"predecessor-version":[{"id":1844,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1841\/revisions\/1844"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=1841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=1841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=1841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}