{"id":1794,"date":"2018-02-07T11:37:58","date_gmt":"2018-02-07T11:37:58","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1794"},"modified":"2018-02-07T11:37:58","modified_gmt":"2018-02-07T11:37:58","slug":"research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/","title":{"rendered":"Research Seminar: Deciphering the varied\u00a0roles of\u00a0primase-polymerases in maintaining genome stability."},"content":{"rendered":"<p><b>Professor Aidan Doherty, <\/b><strong>Genome Damage and Stability Centre, University of Sussex<\/strong><\/p>\n<p><b>Tuesday 13th February, 1.00 p.m., Stacey Lecture Theatre 1<\/b><\/p>\n<p>&nbsp;<\/p>\n<p>To counteract DNA damage and maintain genome stability, cells have evolved a myriad of strategies for repairing and bypassing specific genetic lesions. This seminar will explore our current understand of how potentially lethal DNA lesions are repaired or tolerated by cells. I will describe how a number of recently discovered primase-polymerase (Prim-Pols) dependent repair mechanisms maintain genome stability in mycobacteria. I will also discuss how studying these Prim-Pol centric prokaryotic pathways led to the identification of a distinct damage tolerance enzyme called PrimPol, which operates in novel lesion bypass pathways that maintains genome stability in response to replicative stress in vertebrate cells.<\/p>\n<p>&nbsp;<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/&amp;t=Research Seminar: Deciphering the varied\u00a0roles of\u00a0primase-polymerases in maintaining genome stability.' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Deciphering the varied\u00a0roles of\u00a0primase-polymerases in maintaining genome stability.%20https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/&amp;title=Research Seminar: Deciphering the varied\u00a0roles of\u00a0primase-polymerases in maintaining genome stability.' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/&amp;title=Research Seminar: Deciphering the varied\u00a0roles of\u00a0primase-polymerases in maintaining genome stability.' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Professor Aidan Doherty, Genome Damage and Stability Centre, University of Sussex Tuesday 13th February, 1.00 p.m., Stacey Lecture Theatre 1 &nbsp; To counteract DNA damage &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2018\/02\/07\/research-seminar-deciphering-the-varied-roles-of-primase-polymerases-in-maintaining-genome-stability\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1794"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=1794"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1794\/revisions"}],"predecessor-version":[{"id":1818,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1794\/revisions\/1818"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=1794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=1794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=1794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}