{"id":1716,"date":"2017-10-04T09:37:46","date_gmt":"2017-10-04T08:37:46","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1716"},"modified":"2018-09-19T12:53:22","modified_gmt":"2018-09-19T11:53:22","slug":"research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/","title":{"rendered":"Research Seminar: Molybdenum metabolism in plants, humans and fungi: From atomic structures to patient therapy."},"content":{"rendered":"<p><b>Prof.<\/b> <b>Dr.<\/b><b> Ralf Mendel, <\/b><b>Department of Plant Biology, <\/b><b>Braunschweig<\/b> <b>University of Technology, Germany<\/b><\/p>\n<p><b>Tuesday 10th October, 1.00 p.m., Stacey Lecture Theatre 1<\/b><\/p>\n<p>The transition element molybdenum (Mo) is essential for (nearly) all organisms. We deciphered the principles of Mo-metabolism in humans, plants and fungi: There are more than a dozen proteins involved in Mo uptake, in the conversion into the essential prosthetic group named molybdenum cofactor (Moco), storage and allocation of the cofactor, and posttranslational activation of Mo-enzymes. Mo-metabolism is intimately linked to iron metabolism. A mutation in Moco formation is lethal to the organism. Human patients born with a genetic defect in Moco formation die in early childhood. Based on our molecular plant work, we developed a FDA-approved therapy for these patients.<\/p>\n<ul class=\"kent-social-links\"><li><a href='http:\/\/www.facebook.com\/sharer.php?u=https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/&amp;t=Research Seminar: Molybdenum metabolism in plants, humans and fungi: From atomic structures to patient therapy.' target='_blank'><i class='ksocial-facebook' title='Share via Facebook'><\/i><\/a><\/li><li><a href='http:\/\/twitter.com\/home?status=Research Seminar: Molybdenum metabolism in plants, humans and fungi: From atomic structures to patient therapy.%20https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/' target='_blank'><i class='ksocial-twitter' title='Share via Twitter'><\/i><\/a><\/li><li><a href='https:\/\/plus.google.com\/share?url=https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/' target='_blank'><i class='ksocial-google-plus' title='Share via Google Plus'><\/i><\/a><\/li><li><a href='http:\/\/linkedin.com\/shareArticle?mini=true&amp;url=https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/&amp;title=Research Seminar: Molybdenum metabolism in plants, humans and fungi: From atomic structures to patient therapy.' target='_blank'><i class='ksocial-linkedin' title='Share via Linked In'><\/i><\/a><\/li><li><a href='mailto:content=https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/&amp;title=Research Seminar: Molybdenum metabolism in plants, humans and fungi: From atomic structures to patient therapy.' target='_blank'><i class='ksocial-email' title='Share via Email'><\/i><\/a><\/li><\/ul>","protected":false},"excerpt":{"rendered":"<p>Prof. Dr. Ralf Mendel, Department of Plant Biology, Braunschweig University of Technology, Germany Tuesday 10th October, 1.00 p.m., Stacey Lecture Theatre 1 The transition element &hellip; <a href=\"https:\/\/blogs.kent.ac.uk\/biosciences\/2017\/10\/04\/research-seminar-molybdenum-metabolism-in-plants-humans-and-fungi-from-atomic-structures-to-patient-therapy\/\">Read&nbsp;more<\/a><\/p>\n","protected":false},"author":32117,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[80390,50580],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1716"}],"collection":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/users\/32117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/comments?post=1716"}],"version-history":[{"count":2,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1716\/revisions"}],"predecessor-version":[{"id":1745,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/posts\/1716\/revisions\/1745"}],"wp:attachment":[{"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/media?parent=1716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/categories?post=1716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.kent.ac.uk\/biosciences\/wp-json\/wp\/v2\/tags?post=1716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}