{"id":1328,"date":"2016-05-25T09:50:50","date_gmt":"2016-05-25T08:50:50","guid":{"rendered":"http:\/\/blogs.kent.ac.uk\/biosciences\/?p=1328"},"modified":"2016-05-25T09:50:50","modified_gmt":"2016-05-25T08:50:50","slug":"research-seminar-nf-%ce%bab-a-master-regulator-of-the-cellular-response-to-stress-and-infection","status":"publish","type":"post","link":"https:\/\/blogs.kent.ac.uk\/biosciences\/2016\/05\/25\/research-seminar-nf-%ce%bab-a-master-regulator-of-the-cellular-response-to-stress-and-infection\/","title":{"rendered":"Research Seminar: NF-\u03baB: a master regulator of the cellular response to stress and infection"},"content":{"rendered":"

Professor Neil Perkins, Institute for Cell and Molecular Biosciences (ICaMB), Newcastle University<\/strong><\/p>\n

Tuesday 31st May, 1.00 p.m., Stacey Lecture Theatre 1<\/strong><\/p>\n

 <\/p>\n

My laboratory is interested in how NF-\u03baB subunits are regulated by oncogenes, tumour suppressors and stimuli associated with cancer development and therapy. A theme emerging from these studies has been the importance of context for NF-\u03baB activity and how subunits can both repress as well as activate gene targets, leading to alterations in cell fate. We have demonstrated the importance of post-translational modifications in controlling these activities and argued that the activity of parallel signalling pathways have a critical role in determining NF-\u03baB dependent transcriptional output. Based on this work, together with that from other researchers, we propose that the concerted action of tumour suppressors functions to keep the oncogenic activities of NF-\u03baB subunits in check and that loss of tumour suppressor activity during tumour development is required to unleash these anti apoptotic and pro-metastatic activities in malignant cancer cells. In my talk I will present recent and unpublished data from mouse and cell line models, where we have investigated the role of NF-\u03baB subunits in cancer.\u00a0 These studies underline context dependent complexity of NF-\u03baB signalling in cancer.<\/p>\n