Research Seminar Series
We are excited to offer weekly Research seminars from a range of external speakers to encourage a healthy research environment for our staff and students. The School of Biosciences Research Seminar Series is intended for a broad audience – from undergraduate students to retired professors – and talks cover a range of areas.
The events are currently being held online every Tuesday at 1pm.
Find out more about the upcoming talks below:
2 February 2021 – George Burselm, University of Pennsylvania
Title:”Chemical Approaches for Modulating Lysine Post-Translational Modifications”
Abstract: Post-translational modifications (PTMs) are key modulators of protein function and are crucial for the successful function of a cell. They can act as methods for signal transduction, alter the localization of a protein or signal that a protein is no longer required.
The most widely studied PTM is phosphorylation but reversible covalent modifications of lysine residues have equally important functions. For example, acetylation of lysine residues is the second most observed PTM, after phosphorylation. Our current research is focused on the development of novel chemical approaches to modulate lysine post-translational modifications. This includes both synthetic chemistry and protein engineering approaches to understand lysine modifications as well as chemical biology approaches to modulate them as a potential therapeutic approach.
This seminar will discuss the development and applications of PROTACs for targeted protein degradation of kinases with non-enzymatic functions in cancer as well as the development of novel approaches to modify other lysine PTMS.
16 February 2021 – David Gems, University College London
Title: “What is ageing? Lessons from C. elegans”
23 February 2021 – Charlie Scarff, University of Leeds
Title: “The interacting-heads motif of myosin: from smooth muscle to cardiac”
Abstract: In this seminar, I will present our recent work using cryo-electron microscopy to solve the structure of shutdown smooth muscle myosin, revealing how it is stabilised by multiple interaction interfaces and suggesting how phosphorylation leads to myosin activation. I will discuss how this relates to the IHM found in striated muscle and present our work on the IHM of beta-cardiac myosin, discussing its relevance to inherited heart disease.
2 March 2021 – Lyn Jones, Dana Faber Cancer Institute
Title: “Therapeutic Target Discovery using Chemical Biology”
Abstract: Our group has created several chemical biology technologies to illuminate the interactions of small molecules with proteins in living cells. The impact this area of research has had on therapeutic discovery, target validation and translational pharmacology will be described. The focus of research at the new Center for Protein Degradation at the Dana-Farber Cancer Institute will also be presented.
9 March 2021 – Colin Selman, University of Glasgow
16 March 2021 – Guillaume Jacquemet, Åbo Akademi University, Turku, Finland
Title: “The role of filopodia during the metastatic cascade”
23 March 2021 – Vinay Swaminathan, Lund University, Sweden
Title: “Encoding mechanical information through multi molecular structures: Lessons from Directed Cell Migration.”
30 March 2021 – Phil Mullineaux, University of Essex
6 April 2021 – Alexandre Benedetto, University of Lancaster