A new study by researchers from Kent and Goethe-University Frankfurt shows that the SARS-CoV-2 Omicron variant is less effective than Delta at blocking a cellular defence mechanism against viruses, the so-called ‘interferon response’.
Moreover, cell culture findings indicate that eight important COVID-19 drugs and drug candidates remain effective against Omicron.
The SARS-CoV-2 Omicron variant causes less severe disease than Delta although it is better at escaping immune protection by vaccinations and previous infections. The reasons for this have so far remained elusive.
However, the Kent-Goethe-University Frankfurt study has shown that Omicron variant viruses are particularly sensitive to inhibition by the so-called interferon response, an unspecific immune response that is present in all body cells. This provides the first explanation of why COVID-19 patients infected with the Omicron variant are less likely to experience severe disease.
The cell culture study also showed that Omicron viruses remain sensitive to eight of the most important antiviral drugs and drug candidates for the treatment of COVID-19. This included: EIDD-1931 (active metabolite of molnupiravir), ribavirin, remdesivir, favipravir, PF-07321332 (nirmatrelvir, active ingredient of paxlovid), nafamostat, camostat, and aprotinin.
Professor Martin Michaelis, from Kent’s School of Biosciences, said: ‘Our study provides for the first time an explanation why Omicron infections are less likely to cause severe disease. This is due to Omicron, in contrast to Delta, not effectively inhibiting the host cell interferon immune response.’
Professor Jindrich Cinatl, Institute of Medical Virology at Goethe-University Frankfurt, added: ‘Although cell culture experiments do not exactly reflect the more complex situation in a patient, our data provides encouraging evidence that the available antiviral COVID-19 drugs are also effective against Omicron.’
‘Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates’ [Denisa Bojkova, Marek Widera, Sandra Ciesek, Mark N. Wass, Martin Michaelis, Jindrich Cinatl jr.] is published in Cell Research doi: https://doi.org/10.1101/2022.01.03.474773