Research Seminar: Transcriptional regulation and ageing

Dr. Nazif Alic, Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London

Tuesday 23rd October, 1.00 p.m., Stacey Lecture Theatre 1

Ageing and the associated function decline are of growing social, medical and economic importance. We have been studying how ageing is modulated by transcriptional regulation in an adult animal, the fruit fly Drosophila melanogaster. The talk will focus on our recent findings: I will discuss how the activity of RNA polymerase III in the adult gut limits lifespan downstream of TORC1 and present evidence that a Forhead box O transcription factor programs lifespan in response to a diet with excessive sugar content.