Professor Mark Field Division of Biological Chemistry and Drug Discovery, University of Dundee
Wednesday 1st October, 4.00 p.m., Jennison Lecture Theatre
The control of gene expression, and more significantly gene cohorts, requires tight transcriptional coordination and is an essential feature of probably all cells. In higher eukaryotes, the mechanisms used involve controlled modifications to both local and global DNA environments, principally through changes in chromatin structure as well as cis-element-driven mechanisms. Although the mechanisms regulating chromatin in terms of transcriptional permissiveness and the relation to developmental programmes and responses to the environment are becoming better understood for animal and fungal cells, it is only just beginning to become clear how these processes operate in other taxa, including the trypanosomatids. Recent advances in understanding this process in lower eukaryotes, how this can relate to disease and what it can tell us about the evolution of the nucleus will be discussed.
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