Research Seminar: Glycomic and glycoproteomic strategies: Exploring the glyco in glycoproteins

Professor Anne Dell, CBE, FRS, FMedSci.

Department of Life Sciences, Imperial College London

Monday 24th March, 4.00 p.m., Marlowe Lecture Theatre 1

Much of glycobiology research seeks to understand how sugar oligomers (glycans) on glycoproteins engage with glycan-binding proteins (GBPs also called lectins) to mediate adhesive and signalling events. Such recognition is central to cell-cell communication including interactions between mammalian eggs and sperm, between pathogens, parasites and their hosts, between cells of the immune system, and between the commensal microbial community and the GI tract. In partnership with bioscience collaborators worldwide, my laboratory specialises in the development and exploitation of high sensitivity mass spectrometry for characterising biomedically important glycans with the aim of establishing their functions in health and disease.