Professor Jannette Carey, Department of Chemistry, Princeton University, USA
Monday 3rd February 2014, 4.00 p.m., Marlowe Lecture Theatre 1
The binding of one ligand to a protein can alter the affinity of another ligand; this is the basic definition of allostery. Mechanisms of allosteric signal transmission have been elusive. Results will be presented from a synergistic approach that combines measurements of ligand binding affinity using complementary
experimental methods and molecular dynamics simulations of ligand occupancy and conformational states.