The EBM+ site has now moved to ebmplus.org !
Please update your links.
The EBM+ site has now moved to ebmplus.org !
Please update your links.
One theory is that physicians gave too much credence to hypothesised mechanisms for which there was little or no evidence. If so, the problem was one of method: too little time spent obtaining solid evidence of mechanisms and too little inclination to properly evaluate the evidence that was available.
The next issue of Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences is currently in progress, but some articles from the forthcoming issue have recently been made available online first. One article is by Alexander R. Fiorentino (Public Health and Community Medicine, Tufts) and Olaf Dammann (Public Health and Community Medicine, Tufts & Gynecology and Obstetrics, Hannover Medical School) and is on the topic of the Russo-Williamson thesis.
Enormous effort, by many people, has helped us understand how important good evidence of correlations is in choosing medical treatments, and has characterised how to go about carefully and responsibly performing randomised controlled trials (RCTs) and observational studies on various populations of people. We are trying to do a similar job for understanding – and also explicitly characterising – how evidence of mechanisms helps choose medical treatments.
I’d originally planned to write something this week on the announcement that the Nobel prize in Physiology/Medicine has been awarded to Campbell, Ōmura and Tu. While there’s lots of possible interest here – the Neglected Tropical Disease angle, or the unusual military aspect to be found in the intellectual history of Tu’s work on artemisinin. However, I’ve been distracted by something that came out of S. Lochlann Jain’s excellent new-ish book Malignant: How Cancer Becomes Us, which I’ve been avidly reading this week.