Dr. Anastasia Callaghan
Biological Sciences, University of Portsmouth
Monday 7th April, 4.00 p.m., Stacey Lecture Theatre 1
RNases provide a means of regulation through the processing and degradation of the RNA population. In bacteria, RNase activity can be coordinated through the action of small non-coding RNAs coupled with RNA chaperone protein functioning. Metabolites have also been linked to the regulation of RNase activity, providing yet another means of coordinated RNA population control.
My talk will focus on our studies into the mechanism of an essential bacterial endoribonuclease RNase E, highlight our recent discovery of a link between a molecule of central metabolism and activity regulation of the exoribonuclease PNPase, and conclude with recent work conducted on the RNA chaperone protein Hfq.