Dr. Sarah McClelland, Barts Cancer Institute, Queen Mary University of London
Tuesday 24th January, 1.00 p.m., Stacey Lecture Theatre 1
Chromosomal instability (CIN), the continual gain and loss of chromosomes or parts of chromosomes, and resulting intratumour heterogeneity are key challenges in the treatment of metastatic cancer. Mechanisms underlying chromosomal instability in cancer are unclear, and difficult to determine. I will talk about the approaches our lab is taking to address this problem. In particular I will present our new approach to analyse aneuploidy rates, giving insights into the mis-segregation propensities of individual chromosomes, and how this might allow us to better define the role of aneuploidy in cancer.