Dr. Michael Schlierf, B CUBE – Centre for Molecular Bioengineerig, Dresden University of Technology, Germany
Tuesday 24th May, 1.00 p.m., Stacey Lecture Theatre 1
Over the past decade, numerous single-molecule techniques have become available to study biological molecules. In particular, the observation of conformational changes within these biomolecules or during interactions have become directly accessible. Here, I will present how we develop and apply single-molecule techniques to characterize molecular machines. I will introduce a combination of magnetic tweezers and single-molecule FRET to observe two coordinates simultaneously. I will further discuss how we use single-molecule FRET to study membrane protein folding.