Research Seminar: Biophysics: Investigating the folding, misfolding and assembly of multidomain proteins

Professor Jane Clarke, Department of Chemistry, University of Cambridge

Wednesday 25th March, 4.00 p.m., Stacey Lecture Theatre 1

Most proteins in Nature are not the simple, single domain structures that appear most often in the databases, but larger multidomain proteins and even larger assemblies.  Examples include the giant muscle protein titiin, spectrin, a protein of the cytoskelton, and “hub” proteins and transcription factors, such as CBP and P53, which use disordered regions that fold upon binding to form large multi-protein complexes.  We use a multidisciplinary approach to study the folding, misfolding and assembly of these larger proteins and their complexes.  In my talk I will describe some of our recent discoveries.