Dr. John Overington, BSc PhD MBCS FSB FRSC C.Chem.
European Molecular Biology Laboratory – European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge
Wednesday 29th October, 4.00 p.m., Stacey Lecture Theatre 1
The ChEMBL database contains data from many successful and failed drug discovery projects. By querying the data in specific ways and performing data-mining, it is possible to discover useful rules for the selection of drug targets, rules for lead optimisation, and also for understanding and anticipating attrition during clinical development. During the talk we outline a number of examples of useful and practical rules discovered from the ChEMBL data, covering attrition and polypharmacology, screening file enrichment, and finally how to discover tractable targets from genomic and clinical data.